Plasmepsin



Plasmepsin (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive. The images on the left and right correspond to one representative Plm structure, i.e. the Plasmepsin from Plasmodium falciparum (3fns).

3D Structures of Plasmepsin
Update June 2011

HAP
3fns – PfHAP - Plasmodium falciparum

3fnt – PfHAP + inhibitor pepstatin

3fnu – PfHAP + KNI-10006

Plm I
3qrv – PfPlm I residues 117-457

3qs1 - PfPlm I residues 117-457 + inhibitor

Plm II
1lf4 – PfPlm II

3f9q – PfPlm II (mutant)

2r9b – PfPlm II + peptide inhibitor

1w6h, 2bju, 1lf2, 1lf3, 1lee, 2igx, 2igy – PfPlm II + inhibitor

1w6i, 1xdh, 1xe5, 1xe6, 1me6, 1sme – PfPlm II + pepstatin derivative

1m43 - PfPlm II (mutant) + pepstatin derivative

ProPlm II
1pfz - PfProPlm II

1miq – PvProPlm II – Plasmodium vivax

1qs8 - PvPlm + pepstatin derivative

Plm IV
2anl – Plm IV + statine derivative – Plasmodium malariae

1ls5 - PfPlm IV + pepstatin derivative